The effects of anisomycin (a protein synthesis inhibitor) on
spatial learning and memory in CA1 region of rats hippocampus.
Naghdi N, Majlessi N, Bozorgmehr T.
Department of Physiology & Pharmacology, Pasteur Institute of Iran, Pasteur
Ave., Tehran 13164, Iran. naghdi@institute.pasteur.ac.ir
Inhibition of protein synthesis has been shown to affect long-term memory in a
wide variety of animal species. But little is known regarding the
neuroanatomical location of protein synthesis in different memory tasks. In this
study, the effect of intrahippocampal injection of anisomycin, an inhibitor of
brain protein synthesis on spatial memory was examined in Morris Water Maze. At
first, rats were connulated bilaterally into the CA1 region and then different
doses of anisomycin (1.25-2.5 micro g/0.5 micro l) on its vehicle (saline) were
injected bilaterally into the CA1 region of rats hippocampus 20 min before
training each day. The results showed dose-dependent increases in latencies to
find the invisible platform and traveled distances in anisomycin received group
compared to the control group. Therefore, it appears that protein synthesis
inhibition in the CA1 region of hippocampus impair spatial learning in Morris
Water Maze.
PMID: 12642177
