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Anisomycin

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Anisomycin is an antibiotic which inhibits Protein Synthesis. Also activates p54, MAP Kinases and Stress-Activated Protein Kinases.


Anisomycin  Chemical Formula: C14H19NO4
Anisomycin  Chemical Name: : 2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine
Anisomycin  Molecular Weight: M.W. 265.31
Anisomycin  Solubility: Soluble in DMSO and Ethyl Acetate.

Anisomycin  Boiling Point / Melting Point: BP/MP: 139-141C

Handling: Warning! Toxic. LD50 of < 500 mg / kg.

anisomycin is  an inhibitor of brain protein synthesis shown to have an effect on spatial memory.

"Imagine the possible benefit for people traumatized by haunting memories of terror or tragedy. The day may come when the cure is recalling the trauma, and then erasing it with a shot", wondered Dallas Morning News reporter Tom Siegfried (Aug. 28, 2000) commenting on Dr. Karim Nader's discovery that a fear memory induced in a rat and reactivated after 1 -12 days of storage in the outer part of the brain could be eradicated with a shot of anisomycin, a protein-synthesis inhibitor."

Anisomycin  is approvevd For research use only. Not for human or drug use

 

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Anisomycin references

Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF

The effects of anisomycin (a protein synthesis inhibitor) on spatial learning and memory in CA1 region of rats hippocampus

The effects of anisomycin (a protein synthesis inhibitor) on spatial learning and memory in CA1 region of rats hippocampus

Formation of caspase-3 complexes and fragmentation of caspase-12 during anisomycin-induced apoptosis in AKR-2B cells without aggregation of Apaf-1

Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis.

Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala.

Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration

 

 

 

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